The main adverse reactions of statins, there are liver function abnormalities, holding muscle-related muscle complications, and elevated and some other adverse reactions.Rising blood sugar is a slow activity, so the most important clinical monitoring is liver function and muscle enzymes.
Mr. Chen, 49, has hypertension, hyperlipidemia, and damage to the blood glucose of empty stomach.Of course, such patients have to lower blood lipids, so the doctor ate Mr. Chen with Ru Shuzhang Betin. After January review, low -density lipoprotein cholesterol dropped to 2.09mmol/L, high hemoglobin, 506 μmol/L.As a result, the doctor changed Rosterbatin to Atropine. After January review, low -density lipoprotein cholesterol dropped to 1.85 mmol/L, and the blood uric acid was normal.The doctor asked Mr. Chen to continue taking the medicine. After January review, low -density lipoprotein cholesterol 2.03 mmol/L, muscle enzymes are normal, blood uric acid drops to 368 μmol/L.Alanine aminotransferase is "gifda aminotransferase", which is raised to 51.1U/L. The normal upper limit is 40U/L; the amino aminotransferase of the cottage is "croaramase" 43.2U/L.35U/L.This time, the doctor did not let Mr. Chen stop the medicine, but continued to observe the medicine.
Mr. Chen has increased the mild increase of muscle enzymes and liver enzymes after taking his drugs, soConsider consideration to be related to his drug drugs.
The liver function abnormalities caused by his drug drugs are mainly liver enzyme abnormalities, that is, ascending aminotransferase, and severe liver function damage.Actin-related muscle complications can have myulga, myositis, and muscle disease. In severe cases, horizontal muscles can be dissolved. This is mainly to monitor myoglase ().
How much to consider reduction or stopping the drug?The doctor simply says that 3 times liver enzymes and 4 times myocyrase .
3x liver enzymes means that the transaminase in the liver power rises to more than 3 times or more or more of the upper limit of the normal value;4 times or more.The standard of this muscle was 5 times before.
3 times liver enzyme :
Studies believe that the liver enzymes are slightly elevated after taking his drugsIt is too much, so you can continue to take medicine to observe.
If the height of the liver enzyme is relatively obvious, but within 3 times the upper limit of the normal value, the drug can be reduced or changes to other Hittin.
If transaminase significantly increases, reaches or exceeds three times the upper limit of the normal value, especially accompanied by the increase in blood bilirubin, then the liver must be considered to consider the liverIf you damage, you need to reduce the amount or stop the drug as appropriate.
In addition, the hepatic enzymes after taking statins are also related to the dosage of the service, and it is easy to appear when the dose is large.Therefore, the heine that advocates medium dose is the common amount of daily use, and large doses are not advocated.
Patients with hyperlipidemia have fatty liver at the same time, and the hepases of fatty liver itself will also rise mildly.And his category drugs have improved the non -alcoholic fatty liver, so such patients can also be observed with medication.
Also, the doctor changed Ruhouvastatin to Atropine, because Attica has reduced the role of .
4 times the muscle enzyme :
TakeSome patients will have muscle soreness, discomfort, weakness, and muscle disease after some patients, so they need to monitor myized enzymes.
If there are only symptoms and the muscle enzyme is not high or slightly elevated, some patients can slowly adapt to or can change other citine drugs.Like Mr. Chens muscle enzymes, only a little bit of increased, there is no discomfort, naturally there is no need to stop the medicine.
If the muscle enzyme is elevated obvious, but it has not reached 4 times the normal upper limit value, then according to the patients condition.Patients discontinue the drug if they are discomfort; patients can continue to observe the medication without discomfort.
If the muscle enzyme ≥4 times the upper limit value, then it should be stopped .If the muscle enzyme is ≥10 times the upper limit, the horizontal muscles are dissolved.
The cause of taking a cotton drug causes the muscle enzymes. In addition to the disease, it also has an old age, excessive exercise, too low weight, excessive drinking, and abnormal variations such as some genes and drug metabolismEase or coenzyme Q10 are related to factors.Therefore, elderly people and patients with too low weight should pay attention to control the dose; patients taking the medicine should not drink alcohol; avoid excessive and strenuous exercise; patients taking Xinzanda, Atropine, and Luocetine should also pay attention to avoid excessive consumption of grapefruit.wait.
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