Globally, as the expected life span is extended, age-related diseases, especially nerves and The prevalence of the disease has continued to rise, bringing a heavy burden on the entire society.
Medium stem cell (MSCS) is known for its ability to update and differentiate into multiple cell types.More and more evidence shows that accordance with the therapy of accumulaable stem cells can delay aging and improve the prognosis of various diseases.However, the relationship between accumulating stem cells (HUCMSCS) and aging at the sources of human umbilical cords is currently known.
Recently, the research team from Xiamen University published in Stem Cell Research & AMP; Therapy The magazine published entitled "Multi-omics Evaluation of Clinical-Grade Human mbilical cord -Derived Mesenchymal Stem Cells in Synergistic IMPROVEMENT of Aging Related Disorders in a Senescence-Accelerated Model Model.
This study found that the injection of HUCMSC in the peritoneum can delay the decline of the whole body organs of aging mice and significantly improve the health state of the body.
Researchers first conducted behavioral experiments, and found HUCMSCS treatment 2 through experiments such as object recognition, rotating rods, elevated menu, water maze, etc. After a month, the curiosity of mice enhanced, exercise coordination and balance improved, and the level of anxiety decreased.
Researchers subsequently follow various tissues including brain, heart, lung, skeletal muscle, liver, spleen, kidney and colon The tissue pathology was evaluated and found that the brain tissue of the HUCMSC therapy group mice has been significantly improved, the cardiac function has tended to be normal, and the intestinal degeneration changes have decreased.These results show that HUCMSC therapy can improve a variety of aging organs.
Then, the researchers sequenced the feces of the two groups of mice and found that the intestinal microorganisms of the two groups of mice were significantly different.Specifically, the "probiotics" that the HUCMSC therapy group and the use of humans were significantly recovered with humans.
In general, the study found that HUCMSCS has significant treatment potential in improving the age-related pathology of premature aging mice, for treatment and age Related diseases provide a promising method.
References:
https://estencellres.biomedral.com/articleS/10.1186/s13287---S13287-- 024-03986-9
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