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Injecting Sodium is a proton pump inhibitor (PPI) with high clinical frequency.How about use?
Omeprazole injection indication certificate and specifications
Omepazole sodium for injection, Different products are not exactly the same in the aspects of drug accessories, solution, usage, and dosage of the drug, and the choice of soluble media is different. Therefore, carefully read the instructions before use.use.
Table 1 Omeprazole injection adaptation certificate and specifications
OgilleThe main points of rational use of the rauzole injection [1]
1. Initiative patients are recommended for patients with 60mg as the starting dose, once a day.Give twice when the daily dose exceeds 60 mg;
2. The injection of ohoprazole sodium (for intravenous injection) Dedicated solutions are injected into a small bottle of frozen dry powder. If other solutions are prohibited from dissolving and formulating, it should be slowly injected for at least 2.5 minutes and a maximum rate of 4ml per minute. After dissolving, it must be used within 4h.
3. 3. Injecting Omepazole sodium (only for intravenous drops) should be dissolved at 100ml 0.9%sodium chloride injection or 100ml 5%In glucose injection, venous injection at least 20-30 minutes or longer.After dissolving 5%glucose injection, it should be used within 6 hours; it can be used within 12 hours after dissolving at 0.9%sodium chloride injection.It is forbidden to dissolve and dilute with other solvents or drugs.
Omeprazole injection and commonly used drug compatibility application examples [2]
Compatibility with hydrolysis and nutrients
① Jia Yongxia et al. [3] will convert 200ml sugar injection in the clinical application processInput the patient with 20mg injection of Omeprazole. The solution is changed from colorless to blue and black;
② Huang Yan et al.Use HPLC to determine the content of 4 commonly used solvents in 4 commonly used solvents such as 5%GS, 10%GS, GNS, and 0.9%NS. It is found that the pH value has a great impact on the stability of the solution.The worse the stability, as trying to avoid compatibility with acidic or acidic solutions.The best solvent of Omeprazole should be NS. If it is compatible with 5%GS, 10%GS, GNS, it should be used up within 3H;③ Wang Juan et al. [5]It is reported that compound amino acids (15) dual peptides (2) injection of 0.9%NS + injection of omezole sodium intravenous injection after intravenous injection is completed. Under the sterile operation, it is found that milky white turbidity and floccope appear in the empty needle.
Compatibility with antibacterial drugs
① Huang Wenjuan and others [6] Follow the doctors advice to dissolve the 3g of cephalosporin sodium sodium soda sodium sodium in 100ml physiological saline as the patients intravenous infusion.The color also changes from colorless to pale yellow;
② Liu Di et al. [7] In a deployment error in the outpatient infusion, he found that the injection of omeprazole sodium and dentinazole injectionThe liquid cannot be compatible.
Compatibility with hemostatic drugs
Yang Yaqin et al. [8] After the doctors advice was used for the patients intravenous infusion, after using Omeprazole, he connected to the infusion of hemostasis, and found that the liquid in the infusion tube became orange.
Compatibility with Chinese medicine injection
Kong Zhenzhen, Liu Yimin [9] Sodium olitzole sodium in injection, Schushu Ning injection is dissolved into 5%GS to formulate a suitable concentration solution, and then two solutions are mixed in the test tube. Observe that the mixture will soon change from colorless clarification and change.It became a pale green turbid. After 15 minutes, the liquid in the test tube was divided into two parts. The upper half became a pale yellow clarified liquid. The lower half analyzed the precipitation.
Compatibility with other drugs
Ye Lifen [10]In clinical practice, when it was found that the patient was connected to infusion injection and sodium octoprazole was used in injection, white turbid sediments and floccope appeared in the mixture of the two drugs.The material oscillating cannot be eliminated;
Li Yamin et al. [11] found that when the patients were continuously injected with Omeprazole and amprolytic puff, the inflammatory white liquid appeared in the ink drip tube of the infusion device.It is prompted that there are compatibility taboos.
In addition, there are also reports of omeprazole and methalotoxide, reducing glutathione, and compound glyssid acidoside and other taboos.
Remember!5 Suggestions [2]
PPI and multiple drugs are compatible with taboos,It should be used alone.
PPI, Dedicated solutions should be used. If there is no dedicated solution, it is recommended to use 0.9%NS injection liquid allocation. It is advisable to use 100ml. If you use a 250ml or 500ml infusion, due to the low pH after preparation and the extension of the injection time, it is easier to increase the unstable solutions instability of the solutionsex.
The solution should be cash outUse, avoid light at low temperature, should not be placed for too long. It is best to use it within 2H. For drugs that have changed color reactions, it is not possible to use.
The operation specifications are used to use the disposable equipment as much as possible. Pay attention to dehydration when disinfected.
PPI and other drugsWhen used, after a drug is infused, it should be rinsed into infusion channels with 0.9%NS or other liquids that are not compatible with the two.
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References:
[1]Notice of Guidance Principles (2020 Edition), 2020 version of the clinical application guidance principle of proton pump inhibitors.
[2] Pan Xiaoyan, the research progress of proton pump inhibitors and commonly used drugs [J]. The latest medical information for medical information, 2019,19 (50): 82-83.
[3] Jia Yongxia, Zhang Yali.Analysis and suggestion of Azoli with taboos [J]. The latest medical information exceeding the world, 2017,17 (25): 122-125. [4] Huang Yan, He Haixia, Zhou Yuanda, etc.Sodium and 4 commonly used solvents compatible stability inspections [J]. China Pharmacy, 2015,26 (14): 1948-1949. [5] Wang Juan, Xie Li, Hengyan, etc.) Double peptide (2) Sodium in injection and injection of Omepazole is compatible with taboos [J]. Tianjin Nursing, 2017,25 (4): 354.
[6]Huang Wenjuan, Zhang Shiyuan, Song Jiao. Sodium sodium soda soda soda for injection is compatible with omezole sodium in injection [J]. All science care, 2013,11 (14): 1342-1342. [7] Liu Di, Sun Wei, Wang Xiaoyan, Waiting. Omeprazole and tinidazole injection clinical compatibility analysis [J]. Clinical reasonable medication, 2014,7 (1A): 51.
[8] Yang Yaqin, Chen Xiao, Wang Yongfeng, etc. There are taboos in the injection of Omepazazole and hemostatic sensitivity liquid [J]. Contemporary nurse, 2013, (5): 191.
p ID = "35NFF9CK"> [9] Kong Zhenzhen, Liu Yimin. Injecting use of Omepazole sodium and Shukinning injection combined with taboo analysis [J]. The latest medical information for the world, 2018,18 (75): 131.[10] Ye Lifen. There are taboos with Antinase and Omeprazole in injection [J]. China Rural Medicine, 2014., 21 (2): 43.
