Try to cross all the obstacles on your way forward, never discouraged.
Writing | Ling Jun
Local time FebruaryOn the 16th, Professor Alain Cribier, an inventor of the well -known cardiologist, and a catheter aortic valve replacement (TAVR).
ALAIN CRIBIER is a visionary and imaginative medical scientist. He created the outstanding contributions to the world in the field of heart disease.In 2002, he completed the first TAVR in the world. For more than 20 years, this revolutionary technology saved the life of millions of people, and this changed the direction of the subject development direction of From a simple internal medicine, the Department of Cardiology has shifted to the "half surgery" disease diagnosis and treatment model.
"A really visible person has left." Professor Hadley Wilson, chairman. From the early engaged in heart surgery to TAVR development, he has always been committed to improving the treatment effect of patients and promoting the development of the field. "
Pure aortic valve replacement (TAVR) is a minimally invasive valve replacement surgery. Through interventional catheter technology, artificial heart valve is transported to the aortic valve position, thereby completing artificial valve implantation and restoring the function of the valve.
At the end of 2002, Alain Cribier and colleagues published the worlds first papers in the world on the journal Circulation. He wrote at the endIn the future, this minimally invasive aortic valve stenosis treatment method based on catheter may become an important treatment option.
The prediction of ALAIN CRIBIER has become a reality, and even further, the TAVR technology has changed the treatment of patients with severe aorta stenosis in the world, marking that heart intervention has entered a new era.But when Alain Cribier proposed this concept for the first time in the 1980s, the academic community did not look good and thought it was "extremely stupid idea."
At that time, the only effective active treatment method for patients with aortic valve stenosis (AS) was to perform surgery aortic valve replacement (SAVR).They are mostly elderly elderly people and cannot withstand the trauma and a series of complications brought about by the chest surgery.
In order to solve this problem, Alain Cribier first proposed it for treatment through the balloon aortic valve (BAV).It is considered impossible because people are worried that patients will die because of embolism or ventricular tremor. "Alain Cribier recalled in an interview in April 2023 that when he first decided to treat the patient for the first time, he was where he was.The leader of the Discipline of Cardiology of the University of Lang, France, said to him, "You are crazy, this is unrealistic."
"We should try it, otherwise the patient will also die in the next few weeks!" Alain Cribier responded.
"Okay, if you want to try, go."
For the first time in the world, the aortic valve forming of the balloon was performed.The surgery was very successful, and the patients disease symptoms disappeared within two years.Subsequently, the relevant articles were published in "Liuye Knife", which caused a sensation in the medical community. A large number of doctors came to Rouon, France to learn this technology from ALAIN CRIBIER.
But just a few years later, what worried ALAIN CRIBIBIER worked happened -the previous concern of the academic community is not unreasonable.The defects of lasting benefits have become obvious.This prompted Alain Cribier to start exploring new technologies -TAVR.Since 1988, he started research on the body to prove the feasibility of TAVR surgery.
However, this time, Alain Cribis idea is still opposed by almost the entire academic community. "In their opinion, there are many reasons for TAVR.Deployment devices; inevitable obstruction of the coronary arteries; risk of two -pointed valve injury, aortic rupture, and embolism of the device; poor blood flow dynamic results and not lasting, stroke, insufficiency of the aortic valve, and endometritis. People.It is also believed that since cardiac surgery can meet demand, any new technology will be useless. "
ALAIN CRIBIER has not given up.In a few years, he went to all over the world, France, the United States, Brazil ... I contacted all the medical companies that may be interested in, "but I only received a negative response. The experts of these companies are cardiac surgeons, theyThe inconvenience of this technology was listed, and I was told several times: This is the most stupid idea that has been proposed for technological innovation in history. "
The turn appeared in 1997At a academic conference, Alain Cribis met two engineers from Jone (J & AMP; J) who unexpectedly supported Alain Cribis ideas.In 1999, they established a medical startup to promote the development of TAVR.After a series of failed experiments on the animals, it continued to improve. On April 16, 2002, Alain Cribier performed the worlds first peritable aortic valve replacement for a patient on the verge of death.
Twenty years later, Alain Cribier still remembers every detail of this operation. "We push the valve to guide the wire, pass through the diaphragm, and make the device in the left ventricle out.Pass through the native valve, position the product in the calcification, and inflatter the balloon to release the valve. When we observe that the patients facial color changes from black to pink within a few minutes, the emotions of the entire team are difficult to describe.Tears are full. "
Although the surgery was successful, the surgeon experts still questioned TAVR for more than a year, and believed that they thought that TAVR believed thatThe first success was only lucky. The relevant regulatory authorities also formulated the most stringent test standards, such as "must be a patient who is about to die" to test the effectiveness of TAVR.
ALAIN CRIBIBIER breaks through these obstacles. Under the "terrible" enrollment standard, he and the team conducted the first batch of research on 38 patients and obtained positive results.Beginning in 2005, the regulatory authorities in the United States and Europe began to accept TAVR.Since then, TAVR has gradually become the main choice for treating aortic valve disease.
In October 2010, TAVR was introduced to my country. Ge Junbo, an academician of the Chinese Academy of Sciences and an expert in cardiology, completed the first TAVR in mainland my country.In December of that year, Fuwai Hospital of the Chinese Academy of Medical Sciences successfully performed the second and third surgery for the two patients. By 2023, the TAVR carried out in my country throughout the year has exceeded ten examples.
It is worth mentioning that with the launch of TAVR, various types of menstrual catheter valve therapy (TVT) also ushered in booming.The intervention is metaphorical to the crown of the cardiovascular discipline, so the TVT that has emerged in the past 20 years is undoubtedly the brightest pearl in this crown. "
Looking back on career, Alain Cribier believes that he is luckyFrom the medical school to a resident after graduation, he has always received medical training in the top medical institutions.What he learned is not just clinical technology. "Those great medical predecessors and innovators gave me a lot of inspiration, taught me how to understand unsatisfactory clinical needs and believe that I can be a problem -solving person."
Alain Cribier is also a medical public welfare.At the end of the 1990s, in the same period of the development of TAVR, he also created a Foundation in India to cooperate with relevant companies and commit to the development of heart -related disease -related disease treatment for underdeveloped regions and developing more economic benefits.Essence
After the clinical popularization of TAVR, Alain Cribier spent a lot of time on medical education.Doctors provide standardized training for TAVR and related technologies.
"When you decide to innovate in the medical field, many people will definitely oppose you." Alain Cribier said in an interview, "You must ensure that you are correct, you are correct, you are correct, you are correct, you are correct, you are correct.Keep up and try all the obstacles on your way forward, never get discouraged. "
Source: Medical industry
Responsible editor: Tian TianDongliang
Editor: Zhao Jing
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