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Pifite can cause the concentration of the blood concentration of the west, Laurax, and Midazolon, and chloropyocystum can cause the concentration of propyrine to increase the concentration.During the simultaneous medication process, the clearance rate of chlorolgiabi may increase, the removal rate of propyate may be reduced, and the increase in adverse reactions is observed.Related clinical research results >
In healthy subjects, Lauraci is 1 mg every 12 hours, lasting 3God has no effect on Pharmacodynamic dynamics every 12 hours of sodium sodium.
Sodium propyate can make Lauraxs Under -medicine curve area (AUC) and maximum plasma concentration elevated 20%and 8%, respectively.The sedative scores increased slightly when combined, but there was no statistically significance [1].
When 8 healthy subjects take propyate 250mg twice a day,The clearing rate of the six trials injecting 2mg Laurax was reduced by 40%[2].
Similarly, in another study, the propyrine reduced the veinThe average system clearance rate of 除 is 20%, but the individual mutation has occurred, and the removal rate is also affected by the mutation of the genotype of glucosylinosteroids (UGT) germidase (UGT) of urethosine [3].
1 takes propyate, phenylol, and Female patients have unconscious after receiving a total of 6mg veins.After deactivation, the patient recovered quickly [4].Pateyate may slightly increase the sedative effect of Lauraccium [1].
Question: Dixi 泮+fluoronazole, is it recommended to use clinical recommendations?
Reference materials:
[1] Samara Ee, Granneman RG, WITT GF, Cavanaugy Jh.effect of Valproate on the Pharmacokineticsand Pharmacodynamics of Lorazepam.j clin Pharmacol (1997) 37,442–50.
3E2H "> [2] Anderson GD, Gidal Be, Kantor ED, Wilensky Aj.Lorazepam-Valproate Interaction: Studiesin Normal Subjects and Isolated Perfused Rat Liver.epilepsia (1994) 35,221–5.[3] Chung J-Y, Cho J-Y, Yu K-S,Kim J-R, Jung H-R, Lim K-S, Jang I-J, Shin S-G.Effect of theugt2b15 GENOTYPE on the Pharmacokinetics, Pharmacodynamics, and DRUG Interactions OUS Lorazepam in Healthy Volunteers.clin Pharmacol Ther (2005) 77,486–94.
[4]Lee S-A,Lee JK,Heo K.Coma probably induced by lorazepam–valproate interaction.Seizure(2002)11,124–5.
