Learn a hot search medicine every day
It is consensusThe source of energy depends on the supply of glucose, but it also needs to supplement vitamin B1 (click to get the full medication information).
Glucose will accelerate the consumption of vitamin B 1 in patients. People who have long -term alcoholics are accompanied by gastrointestinal dysfunction and small intestinal mucosal lesions. Generally, vitamin B 1 1 absorbs poorly and lacks.Note may accelerate vitamin B1 consumption [1].If vitamin B 1 is exhausted, it may induce severe Wernicke encephalopathy.
Todays small medicine will discuss the problem of supplementing vitamin B1 to drunk patients.
Why should you supplement vitamin B 1 ?
Vitamin B1 is converted into a thiamine diph phosphate (TDP) in the body, and TDP plays an important role in the energy supply of glucose.
In the cyt carboxylic acid cycle, the TDP will be converted from acetic acid generated by glucose to acetyl -coenzyme A, participating in the pathogenic phosphate pathway, and TDP also participates in the metabolism of the chain amino acid.The deficiency of thiamine or TDP will make the cycle carboxylic acid cycle from being carried out normally, and glucose cannot be converted into tritenia adenosine as energy. [2]
When the vitamin B1 is insufficient, the acetic acid generated during the glucose metabolism cannot be further oxidized, and the metabolism of the energy is obstacle after accumulation.
This metabolic disorders may cause lactic acid accumulation and acid poisoning of brain tissue, interfere with the physiological effects of neurotransmitters, and produce severe neurological complications Wernicke encephalopathy.It is manifested as blurred consciousness and paralysis of the eye muscles. In severe cases, there can be a lack of important neurological function, which is endangered.
Drinking vitamin B 1 Lack, be careful of dementia
The common consequence of long -term drinking is that the cognitive function decreases, and it may even develop into dementia.Psychiatry and psychologist at Vienna Medical University in Austria have proposed an assumption: Iron deposits in the brain can be regarded as a key factor in the decline in cognitive function, and supplementing vitamin B1 can protect the brain from the impact of these deposition.
Large drinking volume will not only cause an increased iron content in the blood, but also cause vitamin B1 deficiency, which is very important for maintaining the blood brain barrier.If these two cases coincide, more iron will be deposited inside the brain, which will eventually lead to oxidative tissue damage.The results of this research were published in " and Alzheimers Magazine.
Injector injection or intramuscular injection?
U.S. Food and Drug Administration: Patients with diagnosis or suspicion of Wernicke encephalopathy should immediately give intravenous vitamin B1, 100mg, then 50-100mg/thenD muscle injection until the patients symptoms are relieved [3].
2018 edition of "Consensus on Chinese Experts in Chronic Alcoholic Brain Diagnosis and Treatment of Chinese Experts": For patients with poison, malnutrition, hypoglycemia, and liver disease in chronic alcoholic alcoholic disorders, enter in intravenous inputBefore glucose, high -dose vitamin B1 should be supplemented by non -intestinal tract, and vein injection of 500mg/d can be used for 3 days.
Note: Vitamin B1 injection instructions clearly stipulateEssence
Practical training:
➤ Digestive, foot gas ... What diseases can vitamin B1 be used forIntersection
➤ The common reason for vitamin B1 is?
➤ Vitamin B1, can it be intravenous injection?
ibuprofen Achictericoinosacorotic acid Meetololfirinoolinohinohinoside Fluorite Dipponone Cycatone Cobe Slutan Soda Calcium Calcate Calcium CalciumRebarin left metropoline sodium gland lactatose monocytic sorchine isteriophyll non -tiste other polypropenopine phenoline phenolphophenol phospholic phospholic oxidamazole AgelomormoneFenbeitetic oxyamine Mengluste sodium 哌 Lasin sodium sodium oxan nerosonoplasma benolic pomolic acid bipolol ▲ Click the medicine to jump to reasonable medication zone
(Ranking is not divided; more medication areas, continue to update ing, so stay tuned)
References:[1] Meng Qingyi Lecture: Analyze the 13 kinds of death methods of acute alcohol poisoning.
[2] Yang Yan, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei, Jia Lei,Xue Yidong, the research progress of Werilickes encephalopathy, practical drugs and clinical.
[3] nishimoto a, userry j, et al. High-Dose Parenteral in time S ENCEPHALOPATHY:Case Series and Review of the Literature [J]. Vivo, 2017, 31 (1): 121.
