A variety of rules in chemistry, but if you observe it, you will find that some rules are actually actually actually rules.It can be broken.In a new research published in the magazine of Science, a group of chemists broke a basic rules that have been restricted by chemists for a century.
This rule is called Brett Rules .The researchers created a molecule that violated this rule, and called for "it is time to rewrite the textbook."
Brett rulesIn 1924, German chemist Brett (Julius Bredt) proposed a criterion for all the molecules applicable to all bridge -linked compounds .This molecules are made up of two shared atomic ring .According to Bretts observation, in the locations of these compounds, the so-called "bridge head" position cannot appear carbon-carbon atomic double bond .Because the double bonds on this position structure will force the molecules to distort, form a distorted 3D shape, making it extremely high instability.
Since then, this guidelines called Brett rules have become important partsApprove.People generally believe that those molecules that violate this rule will not exist because of extremely unstable.
However, new research has overturned this view and shows how to create and use the " Anti -Bretene " (ABO).
Anti -Brettyfin
Olefin is a type of compound commonly used for drug development reactions. Such molecules areContains at least one carbon-carbon atomic double bond.According to the Brett rules, all atoms of the olefin are arranged on a plane.This restricts the imagination of scientists using these molecules to create synthetic molecules, hindering their application in drug discovery.
In fact, in the past century, some chemists have made many efforts to produce a transient ABO.These studies provide support for the existence of ABO, but also show that ABO is indeed unstable and easy to break down.In other words, although some previous studies show that it is possible to create carbon-carbon double bonds on the bridgehead position, but because their reaction conditions are very harsh, chemists cannot successfully synthesize such compounds in a complete form of compounds.EssenceABO is still considered a synthetic intermediate that is difficult to obtain.
Eyfin model.(Figure/neil garg/qrchem)
In the new research, researchers use fluoride source to treat the precursor molecules -silicon -based (pseudo) halide molecules and start the launchThe gentle ones can form an ABO response, which generates a "legendary" molecule of carbon-carbon atomic double bonds located in the bridgehead position.
Since the ABO is extremely unstable, the researchers add a variety of capture agents to these ABOs, which can occur in unstable molecules in unstable molecules"Capture" for them when reaction.In this way, they successfully obtained several complex compounds that can be separated.
This results show that the reaction of ABO and different capture agents can be used to synthesize 3D molecules, which has high practical value for new drug design.
Jump out of the inherent thinking
Some chemists say that this is a milestone research.Now, the research team is exploring other molecules involving ABO and is studying how to synthesize other seemingly impossible structured molecules.The pharmaceutical industry is also vigorously developing chemical reactions that can produce a variety of different three -dimensional structures to discover new drug molecules.
New studies have shown that, in contrast to the traditional concept over 100 years, chemists can create and use ABO to make other molecules.The authors of the new research pointed out that when we recognize the rules that are considered to be unable to violate, creativity will be destroyed.Therefore, they proposed that chemists should jump out of the inherent thinking mode and treat these rules as a guideline, rather than iron law that cannot be violated.
# Creative team:
Compilation: Xiaoyu
Types: Wenwen
# Reference Source: /p>
https://newsroom.ucla.edu/releases/chemists-broke-100- year-out-rule-to-reWrite-textbooks"35cuahj5"> https://www.sclence.org/doi/10.1126/science.adq3519
https://www.nature.com/articles/d41586-0353888-4
# Picture source:
Cover chart chart& amp; First Figure: Neil Garg/QRCHEM
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