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Researchers have identified genetic genetic variations. These variations may indicate that women will lose one of the two X chromosomes with their age growth.This phenomenon is called X chromosome inlaid loss (Mosaic Loss of Chromosome X (MLOX).
Researchers have found that As women grow old, genetic mutations may lead to one chromosomal in two X chromosomesLost , this phenomenon is called X chromosome chromosomal mutation (mosaic chromosomal alterations (MCAS).These genetic variations may play a role in promoting abnormal blood cells (only one X chromosome copy), which may cause several health conditions including .The study was jointly led by researchers at the National Institute of Cancer, a National Institute of Health, and published on June 12, 2024 in the "Nature" magazine.
In order to better understand the reasons and influence of MLOX, the researchers analyzed the cyclic white blood cells of nearly 900,000 women of 8 biological banks, 12 of them%Of women suffer from this disease .Researchers have determined 56 common genetic variations. These variations are located near the genes related to the susceptibility related to autoimmune diseases and cancer. They affect the development of MLOX.In addition, the rare mutation of the FBXO10 gene is more related to the increase in MLOXs risk.
Among women suffering from MLOX, researchers also found a set of genetic mutations on X chromosomes. These variants are compared to the lost X chromosomes on the reserved X chromosomes.More common.One day, these mutations can be used to predict which copy of the X chromosome is retained when the MLOX occurs.This is important because these mutant X chromosomes may have the advantage of growth, which may increase the risk of women with blood cancer.
Researchers also found a correlation between MLOX and more than 1,200 diseases and confirmed the previous discovery, that is, increased risk of mLOX and leukemia and infection caused by pneumonia caused by pneumonia.Easy to be related.
Scientists suggest that future research should pay attention to how mlox interacts with other types of genetic mutations and age -related changes, thereby potentially changing disease risks.
References:
[1] Populating Analysis of Mosaic x Chromosome Identify Geentic Drivers AN d widespream signaturesof cellular select
[2] Genetic Drivers and Cellular Selection of FeffeMale Mosaic X Chromosome
