*For medical professionals for reference
Three questions that need to pay attention to the use of Bastard patients
Writing: Lu Xiong
Stroke refers to the general term of brain tissue necrosis caused by cerebral blood vessel rupture and brain blood obstruction.Patients with early stroke should be given positive treatment to prevent the disease from further development and reduce brain damage.By reducing the cholesterol (LDL-C) and triglyceride (TG) of
Drug guidance of Bastard patients drugs [1]
Drug guidance for patient stroke patients: In clinical applications, the patients condition is needed to reasonably choose the types and dosage of his category drugs to improve the blood lipid level of patients and improve the treatment effect of the disease.During the patients taking statins, medical staff need to explain the precautions of drug treatment for them; when fever, fatigue, myalgia, muscle tenderness, and muscle weakness symptoms, the level of blood phosphate osmotic acid kinoscin is measured.The level is increased and the high level is 5 times. The drug should be stopped immediately to ensure the health of the patient.
Drug guidance of high-risk groups: Clinically for people with high-risk people, including old age, and , rheumatismPatients with a history of heart disease, diabetes, and stroke need to be used reasonably to reasonably use statins to reduce the LDL-C level, thereby controlling the risk of disease.For such people, the blood lipid level needs to be reviewed in the application of statins.For patients with LDL-C levels greater than 2.6 mmol/L, the drug can continue to use the drug, and for patients with the baseline LDL-C level to below 2.1 mmol/L, the patients blood lipid level must be regularly monitored.At the same time, for high-risk patients, the solution to transform the lifestyle of patients, reasonably adjust the amount of fat reduction drugs, strengthen exercise, reduce physical quality, thereby reducing the level of LDL-C, regulating the symptoms of high cholesterol, and exerting clinical efficacy.
Drug guidance of common drugs for common diseases: Clinically for patients with patients with the CCP of the Communist Party of China, it is necessary to take multiple medication schemes for treatment.The influence is also different.Studies have pointed out that for patients with a variety of drugs who take a variety of drugs for clinical diseases, discontinuation of Hisine drugs will increase the risk of heart failure and affect physical health.Based on this, people with multiple drugs should be used for medication. If there is a history of respiratory diseases, history of ischemic heart disease, and a history of cerebrovascular disease, a reasonable adjustment of the drug dose will help reduce medication load.
Can patients with hemorrhagic strokes be used?[2]
The impact of statin drugs on patients with bleeding strokes is still controversial.Some studies believe that Jetine drugs can better prevent stroke and reduce the mortality of patients, but cannot prevent cerebral hemorrhage.Some studies have pointed out that statins can protect the brain of patients with acute cerebral hemorrhage to a certain extent and reduce the patients disability rate.Some studies have believed that statins can increase the risk of cerebral hemorrhage in patients.The hemorrhagic stroke disease mechanism is more complicated. The important links of the disease include the apoptosis and necrosis of the cells, the inflammatory response, the free radical response, and cerebral edema.
How do patients with acute ischemic strokes use statins?
Observation research results show that his prognosis can improve patients with acute ischemia, but it has to be further confirmed by high -quality RCT research.The results of the ASSORT study showed that the early (within 24 h after the onset) was launched with no difference in the efficacy of Biting therapy and delay (7 d after the onset), but patients using hisbin -like drugs before the onset can continue to use the prognosis.The results of Stamina-MRI research indicate that strengthening Betine therapy (Atropine 40 ~ 80 mg or Ruhunzanda 20 mg) can stabilize intracranial atherosclerotic plaques in patients with acute cerebral infarction.Based on the results of the above research, patients with atherosclerotic cerebral infarction should be used as soon as possible after the onset of the onset.The type and therapeutic intensity of statins are determined by individualization [3].
The guidelines at home and abroad are clear that Jetine drugs are the basis for lower cholesterol treatment of patients with atherosclerotic cardiovascular disease.Priority should be used to use his drugs and always retain the cholesterol treatment scheme.The expected decline of different types of LDL-C in different types and doses of Datin-class drugs is shown in Table below [4].
Table: The expected decrease of different types of ldl-c by different types and doses of Datin-class drugs
Figure source: atherosclerotic cardiasis cardiovascular vascularConsensus on the His Consensus of Patients with Cholesterol Drug Therapy 2023
Usage: Short-acting BathsPutinine, Freptine, Putacin) recommends that taking medicine before bedtime, long -acting Histen drugs (Atropus, Ruhunzanda) or jatinoma -like drugs can take medicine for fixed time.Bitten drugs and cholesterol absorption inhibitors usually take once a day.In terms of treatment: Cholesterol drugs usually need to be used for a long time, and it is not recommended to discontinue drugs or reduction.In terms of dosage: Follow the dose requirements in the state of liver damage and kidney damage, as shown in the table below [4].
Table: The dosage of the Usage of Battin L & A Drug
Figure Source: Incense -shaped hard cardiovascular disease patientSociety of cholesterol drug treatment management 2023
References:
[1]. The mechanism of stroke, medication guidance, and adverse reactions of his stroke, drug use guidance and adverse reactions, Chinese drug abuse of prevention and control of the magazine 2023, Vol. 29, No. 10.
[2]. Hisbonic drugs for the treatment of bleeding stroke research progress, China urban and rural enterprise health, September 9th (total 263).
[3]. China ’s acute ischemia diagnosis and treatment guide 2023, Chinese neurology magazine, 2024,57 (6): 523-559.
[4]. Atherosclerotic sclerosis cardiovascular disease patients with cholesterol treatment management expert consensus 2023.
Responsible editor: Old Bean sprouts
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